Fig. 1.

NXS2 tumor growth in mice receiving IC/RV combination therapy. Mice carrying GD2⁺ NXS2 tumors were treated with DMSO p.t. (n = 20), 20 mg RV p.t. (n = 20), IC i.v. (n = 23), or IC/RV in combination (n = 23). Tumors treated with DMSO grew in an exponential fashion. In contrast, tumors treated with RV regressed, but animals developed metastatic tumors and in some animals the primary tumor recurred after cessation of therapy. IC induced anti-tumor activity initially, but eventually tumors progressed. Data shown are tumor volume measurements of the primary tumors at the indicated times. Bars represent the standard deviation. The distribution of tumor volume for the RV group differs from the IC/RV group (P = 0.004 on day 44)