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. Author manuscript; available in PMC: 2011 May 15.
Published in final edited form as: Curr Top Med Chem. 2011;11(6):629–647. doi: 10.2174/1568026611109060629

Figure 4.

Figure 4

(A) Tissue distribution of human ChemR23 determined by dot blot hybridization

(B) Mechanisms of action for RvE1. In a ChemR3-dependent manner, RvE1 activates MAPK in monocytes, rS6 phosphorylation in macrophages, and reduces IL-12 production and migration in dendritic cells. RvE1 also induces expression of an anti-adhesive molecule CD55 on the apical surface of mucosal epithelium, promoting clearance of PMN across mucosal surface. In addition, RvE1 directly interact with BLT1 on human PMN, inhibiting calcium mobilization, NF-κB activation in vitro and PMN infiltration in vivo. Therefore RvE1 gave multi-level and cell-type specific actions, serving as an agonist for ChemR23 on mononuclear and dendritic cells as well as an antagonist for BLT1 signals on PMN.