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. Author manuscript; available in PMC: 2011 May 15.
Published in final edited form as: Sci Transl Med. 2011 Mar 16;3(74):74ra23. doi: 10.1126/scitranslmed.3001564

Figure 2.

Figure 2

Loss of either β-arrestin1 or β-arrestin2 protects mice from alterations in lung mechanics and excessive collagen deposition after bleomycin instillation. (A) Hydroxyproline content in the lungs of β-arrestin1−/−, β-arrestin2−/−, and WT mice 21 days after the instillation of 1.25 U/kg bleomycin. (B) Lung mechanics were measured in anesthetized, paralyzed, and mechanically ventilated mice 21 days after 1.25 U/kg bleomycin or saline administration. Static compliance was determined by fitting the Salazar-Knowles equation to pressure-volume curves. n = 10, *P < 0.05 compared to all other groups by ANOVA followed by Tukey-Kramer honestly significant difference post hoc test.