Table 1.
Net revertants/plate (mean ± SD) and MR (mutagenic ratio) of 1a, 2a, 2b complexes and cisplatin on TA98 and TA100 Salmonella typhimurium strains.
| 1a | 2a | 2b | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Revertans/plate (mean ± SD) | MR | Revertans/plate (mean ± SD) | MR | Revertans/plate (mean ± SD) | MR | Revertans/plate (mean ± SD) | MR | Revertans/plate (mean ± SD) | MR | Revertans/plate (mean ± SD) | MR | |
| TA98 | TA100 | TA98 | TA100 | TA98 | TA100 | |||||||
| Negative control (DMSO) | 87.67 ± 16.8 | 114.67 ± 11.6 | 82.3 ± 9.6 | 128.67 ± 21.2 | 78.7 ± 11.6 | 119.33 ± 6.4 | ||||||
|
| ||||||||||||
| Positive control (cisplatin) >5 μg/plate | >400 | >400 | >400 | >400 | >400 | >400 | ||||||
|
| ||||||||||||
| Dose 1 (0.01 μg/plate) | 86 ± 5.6 | 0.98 | 62 ± 25.4 | 0.54 | 73 ± 1.4 | 0.89 | 121 ± 12.7 | 0.94 | 66.0 ± 5.6 | 0.84 | 141 ± 49.5 | 1.18 |
|
| ||||||||||||
| DOSE 2 (0.1 μg/plate) | 93.5 ± 3.5 | 1.07 | 87 ± 5.7 | 0.76 | 99.0 ± 1.4 | 1.15 | 119.5 ± 2.1 | 0.93 | 97.5 ± 9.2 | 1.24 | 144.5 ± 3.5 | 1.21 |
|
| ||||||||||||
| DOSE 3 (0.5 μg/plate) | 93.5 ± 0.7 | 1.07 | 88 ± 0 | 0.77 | 108.0 ± 14.1 | 1.31 | 134 ± 5.7 | 1.04 | 100 ± 1.4 | 1.27 | 156.5 ± 9.2 | 1.31 |
|
| ||||||||||||
| DOSE 4 (1 μg/plate) | 90 ± 1.4 | 1.03 | 75.9 ± 9.2 | 0.66 | 118.0 ± 2.8 | 1.43 | 132 ± 8.5 | 1.03 | 116.5 ± 3.5 | 1.48 | 141 ± 24 | 1.18 |
|
| ||||||||||||
| DOSE 5 (5 μg/plate) | 79 ± 2.8 | 0.90 | 98 ± 13.4 | 0.85 | 98.0 ± 5.6 | 1.19 | 132.5 ± 2.1 | 1.03 | 81.5 ± 9.6 | 1.04 | 142 ± 16.9 | 1.19 |
|
| ||||||||||||
| DOSE 6 (10 μg/plate) | 106 ± 19.8 | 1.21 | 103 ± 29.7 | 0.90 | 122.0 ± 2.8 | 1.48 | 134.5 ± 3.5 | 1.05 | 125.5 ± 31.8 | 1.60 | 165 ± 9.9 | 1.38 |
|
| ||||||||||||
| DOSE 7 (20 μg/plate) | 101.5 ± 14.8 | 1.16 | 111 ± 1.41 | 0.97 | 103.5 ± 12.0 | 1.26 | 116 ± 5.7 | 0.90 | 89 ± 4.2 | 1.13 | 146 ± 1.4 | 1.22 |
|
| ||||||||||||
| DOSE 8 (30 μg/plate) | 14.5 ± 0.7 | 0.17 | 146.5 ± 21.9 | 1.28 | 114.5 ± 7.78 | 1.39 | 140 ± 4.2 | 1.09 | 109 ± 4.2 | 1.39 | 146 ± 19.8 | 1.22 |