Figure 2. Loss of Prom1 reduces mammary ductal branching.
(a) Severely reduced ductal side branching is apparent in post-pubertal Prom1−/− mammary glands; scale bars: 1 mm. Quantification of branch points per mm2 at (b) 4.5–5.5 weeks and (c) 7.5–9 weeks; n=3–5 mice. (d) Estrus-matched samples from 7.5–9 week old virgin mice confirm that reduced branching in Prom1−/− glands is independent of estrus stage; scale bars: 1 mm. **p<0.01, bars=SD.