Table 2.
Effects of the D2 antagonist L-741,626 and the D3 antagonist PG01037 on D2/D3 agonist-induced yawning behaviora
| Vehicle | 32.0 PG01037 | 1.0 L-741,626 | |
|---|---|---|---|
| Agonist | Yawns (±SEM) | Yawns (±SEM) | Yawns (±SEM) |
| Pramipexole – 0.1 mg/kg | 24.6 (±2.3) | **6.6 (±3.6) | 23.0 (±1.7) |
| 0.32 mg/kg | 8.0 (±2.0) | 4.0 (±1.7) | **22.9 (±3.2) |
| PD-128,907 – 0.1 mg/kg | 20.0 (±1.7) | **9.5 (±1.2) | 21.6 (±3.6) |
| 0.32 mg/kg | 3.6 (±1.7) | 2.1 (±0.7) | **27.6 (±3.1) |
| 7-OH-DPAT – 0.032 mg/kg | 22.5 (±4.9) | **6.5 (±2.3) | 25.6 (±3.9) |
| 0.1 mg/kg | 4.9 (±0.4) | 3.6 (±1.1) | **15.5 (±2.9) |
| Quinpirole – 0.032 mg/kg | 18.3 (±1.1) | **4.9 (±1.1) | 14.9 (±2.1) |
| 0.1 mg/kg | 5.3 (±1.0) | 3.0 (±0.5) | **14.4 (±1.7) |
| Quinelorane – 0.0032 mg/kg | 26.0 (±4.5) | **6.0 (±2.8) | 21.5 (±1.7) |
| 0.01 mg/kg | 2.6 (±0.7) | 2.8 (±0.9) | **17.4 (±3.0) |
| U91356A – 0.1 mg/kg | 14.6 (±1.1) | **4.3 (±1.1) | 16.8 (±1.4) |
| 0.32 mg/kg | 1.5 (±0.6) | 1.1 (±0.1) | **9.6 (±1.9) |
| Apomorphine – 0.032 mg/kg | 12.0 (±3.2) | **2.6 (±1.2) | 13.4 (±2.4) |
| 0.1 mg/kg | 7.3 (±1.6) | 4.1 (±1.1) | **17.5 (±2.1) |
| Sumanirole – 3.2 mg/kg | 11.1 (±2.3) | 8.6 (±1.3) | **19.4 (±0.9) |
a
Antagonists were given as 30 min pretreatments with the total number of yawns recorded during a 20 min period starting 10 min after agonist administration. Data are expressed as mean ±SEM, n=8 rats per group;
*
p<0.05,
**
p<0.01 with respect total yawns of antagonist treated rats compared to vehicle treated rats.