Table 3.
Effects of the D2 antagonist L-741,626 and the D3 antagonist U99194 on D2/D3 agonist-induced hypothermiaa
| Vehicle | 1.0 L-741,626 | 3.2 U99194 | |
|---|---|---|---|
| Agonist | Δ Temp. (±SEM) | Δ Temp. (±SEM) | Δ Temp. (±SEM) |
| Pramipexole – 0.32 mg/kg | −1.50 (±0.11) | **−0.52 (±0.13) | −1.51 (±0.06) |
| PD-128,907 – 0.32 mg/kg | −1.30 (±0.12) | **−0.38 (±0.12) | −1.34 (±0.17) |
| 7-OH-DPAT – 0.1 mg/kg | −1.15 (±0.23) | **−0.53 (±0.10) | −1.12 (±0.17) |
| Quinpirole – 0.1 mg/kg | −0.93 (±0.14) | *−0.23 (±0.15) | −0.84 (±0.22) |
| Quinelorane – 0.01 mg/kg | −0.73 (±0.07) | *−0.52 (±0.05) | −0.67 (±0.05) |
| U91356A – 0.32 mg/kg | −1.25 (±0.17) | **−0.58 (±0.12) | −1.29 (±0.18) |
| Apomorphine – 0.1 mg/kg | −0.74 (±0.13) | *−0.39 (±0.07) | −0.72 (±0.08) |
| Sumanirole – 1.0 mg/kg | −1.05 (±0.10) | *−0.50 (±0.07) | −1.09 (±0.13) |
| 5-HT1A-preferring | |||
| 8-OH-DPAT – 1.0 mg/kg | −2.61 (±0.08) | −2.73 (±0.08) | −2.56 (±0.09) |
a
Antagonists were administered as 30 min pretreatments with Δ Temp. representing the change in core body temperature 30 min after, compared to 1 min prior agonist administration. Data are expressed as mean ±SEM, n=8 rats per group;
*
p<0.05,
**
p<0.01 with respect to Δ Temp of antagonist treated rats compared to vehicle treated rats.