Table 2.
Characteristics of infants in this study
| Characteristica | Medianb (range) for all infants | Medianb (range) for HIV+ infants | Medianb (range) for HIV− infant | P valuec |
|---|---|---|---|---|
| Maternal CD4 count | 410 (10–1,165) | 329 (104–690) | 451 (10–1,165) | 0.016 |
| Maternal viral load | 4.67 (1.77–6.93) | 5.00 (4.01–6.50) | 4.51 (1.77–6.93) | <0.001 |
| Breast milk viral load | 2.59 (1.18–5.29) | 2.72 (1.18–5.29) | 2.57 (1.18–4.03) | 0.47 |
| Infant viral load | 6.25 (4.09–7.54) | |||
| IC50 for Q461d1 | 278 (25–1,573) | 287 (42–1,487) | 263 (25–1,573) | 0.63 |
| IC50 for Q168b23 | 863 (25–1,700) | 677 (92–1,700) | 863 (25–1,700) | 0.9 |
| IC50 for Q842d16 | 47 (12.5–585) | 55 (12.5–416) | 46 (12.5–585) | 0.38 |
| IC50 for BF535.A1 | 229 (12.5–900) | 228 (19–640) | 254 (12.5–900) | 0.43 |
| IC50 for BJ613.E1 | 56 (12.5–751) | 68 (12.5–303) | 54 (12.5–751) | 0.58 |
| IC50 for QD435.A4 | 102 (12.5–741) | 161 (12.5–547) | 82 (12.5–741) | 0.46 |
| IC50 for DU156.12 | 68 (12.5–805) | 79 (12.5–327) | 65 (12.5–805) | 0.88 |
| IC50 for THRO4156.18 | 40 (12.5–333) | 46 (12.5–198) | 35 (12.5–333) | 0.7 |
| Breadth score | 4 (0–8) | 4.5 (0–8) | 4 (0–8) | 0.41 |
| Potency score | 10.0 (1.3–41.3) | 10.8 (1.7–23.8) | 8.7 (1.3–41.3) | 0.68 |
Maternal CD4 counts were taken at the third-trimester visit, maternal and breast milk viral load measurements were taken at time points closest to delivery, and infant viral loads were measured at the first available time point after infection.
There were 100 infants in the study; 32 infants were HIV positive (HIV+), and 68 infants were HIV negative (HIV−). Viral loads are expressed as log10 values, and IC50 values are given for the eight variant viruses. The IC50 values represent the averages of six results from duplicate experiments performed in triplicate. For experiments where there was no detectable neutralization above 50%, values were assigned at the midpoint between zero and the lowest dilution tested.
Determined by the Mann-Whitney U test.