Fig. 1.
Preferential tropism of VSV*ΔG-GP for malignant glioma cells. Different tumor cell lines (A) and “differentiated” as well as undifferentiated human neural stem cell (hNSC) and human glioma stem cell (hGSC) cultures (B) were infected with 10-fold serial dilutions of VSV*MQΔG-G and VSV*MQΔG-GP. Titers were analyzed 16 h postransduction by flow cytometry based on GFP expression. Relative titers were determined in relation to BHK-21 as the reference cell line. The data shown represent the means and standard deviations of the results of at least three infection experiments. VSV*MQΔG-G and VSV*MQΔG-GP infection titers were compared. HCC, hepatocellular carcinoma; *, P < 0.05; **, P < 0.01; ***, P < 0.001.