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. 2011 Feb 23;31(8):2835–2842. doi: 10.1523/JNEUROSCI.5412-10.2011

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Copyright © 2011 the authors 0270-6474/11/312835-08$15.00/0

This article is freely available online through the J Neurosci Open Choice option.

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Figure 6. — Correlation of opioid withdrawal-induced effects. This graph shows the correlation of the opioid withdrawal-induced effects on MPRF activity and pain in responders (red) and nonresponders (blue). A significant negative correlation (r = 0.61; p = 0.03) is observed only in responders. The opioid withdrawal-induced effects on MPRF neuronal response (percentage BOLD signal change) and pain intensity to thermal noxious stimulation (X) were defined by (X_{postinfusion (opioid)} − X_{preinfusion(opioid)}) − (X_{postinfusion (saline)} − X_{preinfusion(saline)}).