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HeLa cells microinjected with antisense oligos and dextran-fluorescein were after incubation labeled for the SC35 protein (in red). U1 oligo (A), U2a oligo (B), U2B oligo (C), unrelated oligo (D); the appearance of the speckles in untreated cells (part of the nuclear profile is seen) is the same. See text for the detailed description.
