Table 1.
Echocardiography: Effects of Increased ACVI Expression
| AC-Off (n = 15) | AC-On (n = 19) | ||||||
|---|---|---|---|---|---|---|---|
| Before Rx | 5 Weeks After Rx | Change | Before Rx | 5 Weeks After Rx | Change | p Value | |
| HR (beats/min) | 394 ± 14 | 412 ± 15 | 18 ± 13 | 408 ± 11 | 430 ± 12 | 21 ± 17 | 0.88 |
| EDD (mm) | 5.5 ± 0.1 | 5.6 ± 0.1 | 0.1 ± 0.1 | 5.9 ± 0.2 | 5.9 ± 0.2 | 0.03 ± 0.1 | 0.70 |
| ESD (mm) | 4.8 ± 0.1 | 5.0 ± 0.2 | 0.2 ± 0.1 | 5.1 ± 0.2 | 5.0 ± 0.3 | 0.1 ± 0.1 | 0.17 |
| PWd (mm) | 0.66 ± 0.03 | 0.57 ± 0.02 | −0.09 ± 0.03 | 0.64 ± 0.02 | 0.61 ± 0.02 | −0.03 ± 0.02 | 0.14 |
| IVSd (mm) | 0.48 ± 0.02 | 0.47 ± 0.02 | −0.01 ± 0.02 | 0.49 ± 0.03 | 0.48 ± 0.02 | −0.02 ± 0.02 | 0.89 |
| FAC (%) | 13 ± 1 | 12 ± 1 | −1 ± 1 | 13 ± 1 | 16 ± 1 | 3 ± 1 | 0.0001 |
| LVEF (%) | 24 ± 1 | 22 ± 1 | −2 ± 1 | 24 ± 2 | 28 ± 2 | 5 ± 1 | 0.0001 |
Values represent mean ± SE. The p values are from the Student t test comparing changes in each parameter between groups (2-tailed, unpaired).
ACVI = adenylyl cyclase VI; EDD = end-diastolic diameter; ESD = end-systolic diameter; FAC = fractional area change; HR = heart rate; IVSd = interventricular septal diastolic wall thickness; LVEF = left ventricular ejection fraction; PWd = posterior diastolic wall thickness; Rx = treatment.