Table 3.

Echocardiography: Nontransgenic C57BL/6 Mice ± Doxycycline

	Doxycycline (n = 7)			No Doxycycline (n = 11)
	5 Weeks After MI	10 Weeks After MI	Change	5 Weeks After MI	10 Weeks After MI	Change	p Value
HR (beats/min)	443 ± 20	459 ± 30	16 ± 31	464 ± 10	453 ± 24	−11 ± 18	0.43
EDD (mm)	4.9 ± 0.4	5.3 ± 0.5	0.5 ± 0.2	5.0 ± 0.3	5.3 ± 0.4	0.3 ± 0.2	0.46
ESD (mm)	4.3 ± 0.4	4.8 ± 0.6	0.6 ± 0.2	4.3 ± 0.4	4.7 ± 0.5	0.3 ± 0.2	0.52
PWd (mm)	0.6 ± 0.1	0.5 ± 0.1	−0.1 ± 0.1	0.6 ± 0.1	0.6 ± 0.05	−0.01 ± 0.04	0.81
IVSd (mm)	0.6 ± 0.1	0.6 ± 0.04	0.01 ± 0.04	0.6 ± 0.03	0.6 ± 0.02	−0.02 ± 0.03	0.61
FAC (%)	12 ± 2	11 ± 2	−0.6 ± 1.0	14 ± 2	14 ± 2	−0.1 ± 1.0	0.74
LVEF (%)	19 ± 4	20 ± 4	1 ± 2	22 ± 4	21 ± 4	−1.1 ± 1.5	0.32

Values represent mean ± SE. p value is from Student t test comparing changes in each parameter between groups (2-tailed, unpaired). Data from nontransgenic C57BL/6 mice (strain-matched). Experimental protocols were identical. Doxycycline was given continuously from 10 days before to 5 weeks after MI, or was not given (No Doxycycline group).

Abbreviations as in Table 1.