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Aβ failed to block hippocampal LTP in SOD-2 transgenic mice. A, HFS-induced LTP (dark gray triangles, n = 8) was blocked by Aβ1-42 (500 nm) in wild-type (WT) hippocampal slices (light gray triangles, n = 7). In slices from SOD-2 transgenic mice, HFS was able to induce LTP in the presence of Aβ1-42 (500 nm; gray circles, n = 5). B, Cumulative data showing mean fEPSP slopes 80 min post-HFS.
