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. 2001 Feb;12(2):407–419. doi: 10.1091/mbc.12.2.407

Figure 2.

Figure 2

Identification of three nonessential histidine kinases in fission yeast. (A) Diagrammatic representation of the domain architecture of S. pombe (S.p.) Mak1p, Mak2p, and Mak3p compared with the S. cerevisiae (S.c.) Sln1p and C. albicans (C.a.) HK1 histidine kinases. The positions of the following domains are shown in these molecules: putative serine/threonine kinase domain (diagonally hatched bar), GAF domain (gray bar), PAS/PAC motifs (open bar), histidine kinase (black bar), and response-regulator domain (vertically hatched bar). The Mak1p, Mak2p, and Mak3p sequences appear in the SWISSPROT and EMBL databases under the accession numbers AL157734, Z98978, and AL031543, respectively. (B) S. pombe histidine kinases control cell size at cell division via Mcs4p. Wild-type (mcs4+) (JM 1059), mcs4(D412N) (VB1692), Δmcs4 (JM1468), Δmak1 Δmak2 Δmak3 (VB1971), or Δmak1 Δmak2 Δmak3 Δmcs4 (VB1925) cells were grown to log phase in minimal medium and photographed by using Normarski optics.