Table 1.
Demographic characteristics of cohort
| Autopsy cohort (n = 61) | Additional genotyped patients (n = 24) | |
|---|---|---|
| Gender | 39 males (63.9%) | 12 males (50%) |
| 22 females (36.1%) | 12 females (50%) | |
| Site of onseta | 37 spinal (60.7%) | n/a |
| 20 bulbar (32.8%) | ||
| Age at onset, median years (IQR) | 57 (41–73) | 62 (55.5–71.5) |
| ALS-FRS-Rb, median (IQR) | 19 (15–22) | n/a |
| Duration, median months (IQR) | 31 (3–59) | n/a |
The additional cohort of 24 individuals was composed of individuals in whom the ALS diagnosis was certain, but histopathological or clinical data were less complete
n/a not available
a
For four patients in the autopsy cohort and most patients in the additional cohort, site of onset was not clear from chart review
b
Most proximate score to death