Figure 3.

Effect therapeutic treatment with T. catigua extract (200 mg kg⁻¹, p.o.), morphine (4 mg kg⁻¹, s.c.) and indomethacin (5 mg kg⁻¹, i.p.) on the mechanical hypersensitivity induced by carrageenan (300 μg/50 μl/paw, i.pl.) in mice. (a) Time-course of the anti-hypernociceptive effect; (b) AUC of the anti-hypernociceptive effect. Results represent the mean  ±  SEM; n = 6–8 animals per group. *P < .05 significantly different from PBS + PBS-treated mice; ^# P < .05 significantly different from PBS + carrageenan-treated mice; ^a P < .05 significantly different from morphine and indomethacin-treated mice (ANOVA followed by Newmann-Keuls post-hoc test).