Table 1.
Physicochemical properties of ascorbic acid derivatives.
| Ref | ||
|---|---|---|
| ASC-G | ||
| Solubility | 714 g/L at 19 ± 1°C | * |
| Surface tension | 71 mN/m (0.99 mg/mL) | * |
| Stability | Half-life at 50°C: >1 year at pH 4, 7, and 9 | * |
| Toxicity | Acute oral toxicity (LD50): 2500 mg/kg (Rat) | * |
| Acute dermal toxicity (LD50): >2000 mg/kg (Rat) | ||
|
| ||
| ASC-8 | ||
| Critical micelle concentration | 6 × 10−3 mol/L (pH2) | [1] |
| Hydrodynamic radius | 25.4 Å | [1] |
| Head group area | 57.6 Å2 | [1] |
| Aggregation number | 84 | [1] |
|
| ||
| ASC-P | ||
| Solubility | 5.6 mg/mL at 25 ± 0.1°C | ** |
| Toxicity | Acute oral toxicity (LD50): 25000 mg/kg (Mouse) | ** |
| Acute dermal toxicity (LD50): >3000 mg/kg (Guinea pig) | ||
|
| ||
| ASC-S | ||
| Solubility | Insoluble in water, soluble in ethanol | *** |
|
| ||
| ASC-DP | ||
| Solubility | Insoluble in water | **** |
| Stability | Stable in aqueous media at pH 4, 7, and 10 | **** |
| Stable in methanol | **** | |
| Safety | Oral administration: up to 1.25 mg/kg body weight daily | ***** |
*2-O-α-D-glucopyranosyl-L-ascorbic acid, Full Public Report National Industrial Chemicals Notification and Assessment Scheme, file no. STD/1056, 2003.
****Unpublished data.
*****http://www.hc-sc.gc.ca/.