Table 2.

Selected diseases discussed	OMIM #	Drosophila genes discussed	Loss of function NMJ phenotypes
Hereditary Spastic Paraplegia 3	#182600	Atlastin	more boutons, bouton clustering, satellite boutons, dense MT network, impaired movement
Hereditary Spastic Paraplegia 4	#182601	Spastin	more boutons, bouton clustering, satellite boutons, dense MT network, impaired movement
Hereditary Spastic Paraplegia 6	#600363	Spichthyin	more boutons, bouton clustering, dense MT network
Multiple Sclerosis	#126200	Ema	more boutons, increased synaptic area, enlarged endosomes
Huntington's Disease	#143100	CIP4	more boutons, satellite boutons, increased synaptic area
Amyotrophic Lateral Sclerosis 8	#608627	Vap-33-1	fewer and larger boutons, severely disorganized and fragmented MT network
Spinal Muscular Atrophy I, II, III	#253300, #253550, #253400	Smn	fewer and larger boutons