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. 2010 Nov 15;1:117. doi: 10.3389/fmicb.2010.00117

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Copyright © 2010 Miyata, Kitaoka, Wieteska, Frech, Chen and Pukatzki.

This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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The V. cholerae Type VI Secretion System (T6SS). (A) The T6SS gene clusters. The three gene clusters contain genes of predicted (blue) and unknown (gray) functions. VCA0117 encodes the gene designated vasH. Also shown is the VasH-dependent regulation of the T6SS genes. (IHF, integration host factor). (B) Model for T6SS mechanics. Structural components form the base of the T6SS in the bacterial inner and outer membrane. A surface-exposed Hcp tube decorated with a VgrG trimer punctures a vesicular membrane to translocate effectors into the host cell (see text for details).