Table 1.

Fic and adenylyl transferase AMPylators.

	Kingdom	Name	Organism	Target	Function	Structure	References
Fic domain catalytic motif:HPFx[D/E]GN[G/K]R	Prokaryotic	VopS	Vibrio parahaemolyticus	Rho family GTPases	Pathogenicity: disable cytoskeleton	PDB ID 3LET	Yarbrough et al. (2009)
		IbpA	Histophilus somni	Rho family GTPases	Pathogenicity: disable cytoskeleton	PDB ID 3N3U and 3N3V	Worby et al. (2009), Xiao et al. (2010), Zekarias et al. (2010)
		AnkX	Legionella pneumophila	?	Pathogenicity: disruption of vesicular transport	No	Pan et al. (2008), Roy and Mukherjee 2009
	Eukaryotic	HYPE	Homo sapiens	?	?	No	Worby et al. (2009)
		CG9523	Drosophila melanogaster	?	?	No	Kinch et al. (2009)
Adenylyl transferase domain catalytic motif: G-x11-D-x-D	Prokaryotic	GS-ATase (GlnE)	Many	Glutamine synthetase	Regulation of glutamine synthesis	PDB ID IV4A and 3K7D	Mangum et al. (1973), Jiang et al. (1998, 2007a, 2007b)
		DrrA/SidM	Legionella pneumophila	Rab1b GTPase	Pathogenicity: Cell rounding, cytotoxicity	PDB ID 3NKU	Muller et al. (2010), Murata et al. (2006)