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Affect of MK CM concentration on osteoclastogenesis. Increasing concentrations of GATA-1 deficient and C57BL/6 MK CM similarly inhibited OC development. A significant, greater than 65% reduction in the number of OCs formed was observed with just 3% CM. With 30% CM from either C57BL/6 or GATA-1 deficient MKs, complete inhibition in OC formation was seen. * Denotes a significant difference (p<0.05) in OC number compared to control groups cultured without CM (0%).
