Table 2.

Median viral load (VL) drop in untreated spontaneous clearers and progressors

	Spontaneous clearers (SC) (95% CI)	Progressors		HR* (95% CI)	p Value
		(PV) (95% CI)	(FV) (95% CI)
Maximum HCV VL log10 (IU/ml) drop within 100 days from first positive PCR	2.20 (1.65 to 5.03)	0.03 (–0.33 to 0.23)	0.58 (0.25 to 0.96)	1.78 (1.45 to 2.18)	<0.0001†
Maximum HCV VL log10 (IU/ml) drop within 200 days from first positive PCR	3.46 (1.70 to 7.05)	0.17 (–0.06 to 0.38)	0.85 (0.45 to 1.77)	1.68 (1.40 to 2.02)	<0.0001†

^*HR represents change in hazard per log₁₀ change in VL.

^†Highly significant p value <0.01.

HCV, hepatitis C virus.