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. 2011 Apr 13;93(6):1248–1254. doi: 10.3945/ajcn.110.009043

TABLE 3.

Plasma amino acid concentrations in healthy control and partial–ornithine transcarbamylase–deficient (partial-OTCD) subjects who received either control or sodium phenylbutyrate (10 g · m−2 · d−1) treatment1

Control subjects (n = 7)2
Partial-OTCD subjects (n = 7)2
P values
Amino acid Control Phenylbutyrate Control Phenylbutyrate Pooled SEM TRT Gen TRT × Gen
μmol/L μmol/L μmol/L
Leucine 135 94 130 95 10.8 <0.001 <0.869 <0.608
Isoleucine 61 45 67 53 5.5 <0.001 <0.364 <0.852
Valine 216 161 225 164 14.2 <0.001 <0.751 <0.653
Methionine 29 28 36 30 1.9 <0.007 <0.074 <0.067
Cysteine 30a 22b 22a,b 25a,b 3.7 <0.264 <0.583 <0.006
Phenylalanine 80 72 76 79 3.9 <0.422 <0.771 <0.063
Tyrosine 66 80 83 93 6.1 <0.022 <0.063 <0.617
Lysine 204 195 210 193 14.3 <0.047 <0.935 <0.524
Arginine 79 81 67 64 6.3 <0.905 <0.081 <0.539
Ornithine 49 43 56 47 5.4 <0.006 <0.451 <0.519
Citrulline 27 23 27 19 3.7 <0.001 <0.683 <0.099
Glutamate 30 40 55 68 8.7 <0.019 <0.026 <0.669
Glutamine 571 531 720 680 44.6 <0.081 <0.017 <0.985
Aspartate 4 2 5 6 1.2 <0.519 <0.085 <0.227
Asparagine 73 84 83 68 8.0 <0.675 <0.764 <0.033
Ammonia 12 7 33 20 9.2 <0.002 <0.193 <0.131
1

TRT, treatment (control compared with phenylbutyrate treatments); Gen, genotype (control compared with partial-OTCD subjects); TRT × Gen, interaction of main effects. Data were analyzed by using mixed models (fixed effects for TRT, Gen, and TRT × Gen; random effects for subject). Values with different superscript letters differed (Tukey-Kramer–adjusted P < 0.05).

2

Values are means.