Figure 5.

Representative immunoblots of insulin-stimulated phosphorylation of Akt on both Thr³⁰⁸ (a) and Ser⁴⁷³ (b) in soleus muscles of fructose chow-fed rats receiving oral administration of DBT (2.5 g kg⁻¹ per day) or rosiglitazone (4 mg kg⁻¹ per day) for 14 days. Rats that did not receive any treatment were given the same volume of vehicle (distilled water) used to dissolve the test medications. Findings were reproduced on four separate occasions. Quantification of protein levels expressed as mean with SD (n = 5 per group) in each column. ^a P < .05 and ^b P < .01 represents the level of significance compared with the values with vehicle-treated standard chow-fed rats, respectively.