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. 2011 Feb 13;2011:248481. doi: 10.1093/ecam/nep173

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Copyright © 2011 K. Tominaga et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Changes in gastric emptying by 5-HT, 5-HT₃, 1-(3-chlorophenyl) biguanide, and 5-HT₄ (mosapride) agonists in rats: intraperitoneal injection of 5-HT (0.1 and 1.0 mg kg⁻¹) significantly delayed gastric emptying compared with the controls (from 81.7 ± 4.5 to 50.2 ± 8.8 and 38.5 ± 4.3%) in a dose-dependent manner. The 5-HT₃ agonist 1-(3-chlorophenyl) biguanide significantly delayed gastric emptying, similar to 5-HT (from 78.8 ± 3.1 to 40.2 ± 6.4%), whereas the 5-HT₄ agonist mosapride (0.3–3.0 mg kg⁻¹) accelerated it (from 75.6 ± 5.7 to 90.7 ± 2.3%). Each column represents the mean ± SEM. of eight rats. *P < .01: significantly different from the control group.