Table 1.
Fisher's exact test | p1 | p2 | p3 | p4 | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Data set 1 (n = 4) |
Data set 2 (n = 10) |
Data set 1 (n = 4) |
Data set 2 (n = 10) |
Data set 1 (n = 6) |
Data set 2 (n = 5) |
Data set 1 (n = 3) |
Data set 2 (n = 5) |
|||
High stage (3 or 4) | 0,053* | 0,056 | 0,330 | 0,691 | 0,075 | 0,355 | 0,324 | 1,000 | ||
Stage 4 | 0,029* | 0,001** | 0,241 | 0,062 | 0,088 | 0,304 | 0,124 | 0,696 | ||
Outcome | 0,139 | 0,051* | 0,555 | 1,000 | 0,072 | 1,000 | 0,728 | 0,070 | ||
MNA | 0,208 | 0,375 | 0,208 | 0,141 | 0,001** | 0,003** | 0,324 | 1,000 | ||
Del1p | 0,088 | 0,210 | 0,088 | 0,067 | 0,018* | 3,9E-04** | 0,360 | 0,589 | ||
Del11q | 0,441 | 0,235 | 0,559 | 0,013* | 0,160 | 0,622 | 0,051* | 0,622 | ||
Gain17q | 0,063 | 0,128 | 0,365 | 0,109 | 0,058 | 1,000 | 0,458 | 0,651 | ||
ANOVA one-way | ANOVA significance | FC p1 | FC p2 | FC p3 | FC p4 | |||||
Data set 1 | Data set 2 | Data set: 1 | 2 | Data set: 1 | 2 | Data set: 1 | 2 | Data set: 1 | 2 | |
ALK | 1,1E-03** | 0,277 | -1,8 | -0,5 | 1,2 | 0,0 | 3,6 | 1,4 | -1,0 | -0,6 |
BIRC5 | 6,1E-06** | 1,4E-05** | -2,9 | -1,7 | 2,9 | 2,0 | 7,8 | 2,1 | -3,0 | -2,6 |
CCND1 | 0,011* | 0,003** | 0,5 | 1,1 | 2,0 | 0,4 | 1,0 | 0,1 | -1,9 | -2,6 |
MYCN | 2,0E-04** | 7,0E-04** | -0,6 | -0,3 | 0,4 | -0,4 | 12,6 | 2,4 | -3,5 | -1,4 |
NTRK1 | 6,7E-04** | 1,1E-05** | 3,7 | 3,4 | 3,6 | 0,7 | 0,1 | -4,0 | -0,3 | -2,6 |
PHOX2B | 0,006** | 3,4E-08** | 0,5 | 0,6 | 2,0 | 1,0 | 1,2 | 0,7 | -2,3 | -3,2 |
Fisher's exact test: Each cluster (p1, p2, p3, or p4) versus the other clusters combined. n = the number of samples in each subgroup. High stage = INSS stage 3 and 4; outcome = dead of disease; MNA = MYCN amplification; del = deletion. Significance is marked by stars: * p < 0.05, ** p < 0.01. ANOVA one-way: The differential expressions from six genes in PCA clusters (p1-p4) were tested by an ANOVA one-way test. Significance is marked by stars: * p < 0.05, ** p < 0.01. FC = The log2 fold change of genes in each PCA group compared to the other groups combined.