Table 2.
Percentage of subjects displaying each of the 17 side effects of methylphenidate during each treatment condition (Parent Ratings)*
| Side Effect | Total Side Effects | Severe Side Effects | ||||
|---|---|---|---|---|---|---|
| Placebo | Active | P-value | Placebo | Active | P-value | |
| Insomnia (%) | 25 | 47 | 0,00 | 7 | 13 | 0,08 |
| Nightmares (%) | 15 | 12 | 0,39 | 2 | 1 | 0,68 |
| Stares a lot (%) | 26 | 31 | 0,30 | 4 | 4 | 0,96 |
| Talks less (%) | 13 | 23 | 0,01 | 2 | 4 | 0,49 |
| Uninterested (%) | 15 | 14 | 0,69 | 2 | 3 | 0,46 |
| Decreased Appetite (%) | 20 | 49 | 0,00 | 4 | 17 | 0,00 |
| Irritable (%) | 52 | 54 | 0,68 | 12 | 10 | 0,57 |
| Stomachaches (%) | 17 | 25 | 0,10 | 4 | 4 | 0,92 |
| Headaches (%) | 19 | 31 | 0,01 | 2 | 8 | 0,02 |
| Drowsiness (%) | 8 | 14 | 0,09 | 0 | 2 | 0,08 |
| Sadness (%) | 27 | 30 | 0,57 | 4 | 8 | 0,09 |
| Prone to crying (%) | 32 | 43 | 0,05 | 7 | 6 | 0,88 |
| Anxious (%) | 37 | 34 | 0,54 | 7 | 4 | 0,25 |
| Bites fingernails (%) | 21 | 22 | 0,86 | 8 | 8 | 0,76 |
| Euphoria (%) | 31 | 20 | 0,03 | 8 | 5 | 0,21 |
| Dizziness (%) | 7 | 5 | 0,39 | 0 | 1 | 0,15 |
| Tics/Nervous movements (%) |
14 | 15 | 0,93 | 4 | 2 | 0,33 |
* % refers to the percentage of subjects in whom the side effect was rated 1 or higher on the scale of severity (1 to 9); % severe refers to the percentage of subjects in whom the side effect was rated 7 or higher.