Table 3.
Top regulated transcripts in human tendinopathy as determined by microarray analysis
| Gene Symbol | Description | p-value | q-value | Fold Change |
|---|---|---|---|---|
| ADAM12 | A disintegrin and metalloproteinase domain 12 | 1.57E-05 | 2.09E-04 | 5.6 |
| AP3M1 | Adaptor-related protein complex 3, mu 1 subunit | 1.24E-03 | 1.91E-03 | 1.7 |
| ARL7 | ADP-ribosylation factor-like 7 | 1.43E-03 | 2.11E-03 | 4.0 |
| ARPC5 | Actin related protein 2/3 complex, subunit 5 | 3.63E-05 | 2.10E-04 | 1.8 |
| ASXL1 | Additional sex combs like 1 (Drosophila) | 1.11E-03 | 1.78E-03 | 1.8 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70 kDa | 4.18E-05 | 2.10E-04 | 2.5 |
| BACE2 | Beta-site APP-cleaving enzyme 2 | 3.17E-06 | 8.01E-05 | 1.9 |
| BNC2 | Basonuclin 2 | 1.08E-04 | 3.15E-04 | 2.9 |
| CA12 | Carbonic anhydrase XII | 3.57E-05 | 2.10E-04 | 2.8 |
| CTHRC1 | Collagen triple helix repeat containing 1 | 5.20E-04 | 1.10E-03 | 4.4 |
| DDEF1 | Development and differentiation enhancing factor | 2.83E-05 | 2.10E-04 | 2.1 |
| DOCK10 | Dedicator of cytokinesis 10 | 7.91E-03 | 8.11E-03 | 3.3 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 4.80E-03 | 5.34E-03 | 2.9 |
| FOXP1 | Forkhead box P1 | 4.67E-05 | 2.10E-04 | 1.7 |
| GPR161 | G protein-coupled receptor 161 | 2.76E-04 | 6.89E-04 | 1.9 |
| IGFBP3 | Insulin-like growth factor binding protein 3 | 7.29E-03 | 7.67E-03 | 3.5 |
| IL13RA2 | Interleukin 13 receptor, alpha 2 | 2.80E-03 | 3.50E-03 | 3.5 |
| ILK | Integrin-linked kinase | 1.00E-04 | 3.15E-04 | 1.6 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 4.73E-05 | 2.10E-04 | 1.5 |
| ITGB1 | Integrin, beta 1 | 3.52E-04 | 8.29E-04 | 1.7 |
| ITPKB | Inositol 1,4,5-trisphosphate 3-kinase B | 7.37E-04 | 1.34E-03 | 2.5 |
| JAG1 | Jagged 1 (Alagille syndrome) | 1.90E-03 | 2.52E-03 | 3.1 |
| KCNE4 | Potassium voltage-gated channel 4 | 8.19E-03 | 8.19E-03 | 3.4 |
| LAMA4 | Laminin, alpha 4 | 6.73E-04 | 1.31E-03 | 3.4 |
| LRRC15 | Leucine rich repeat containing 15 | 3.50E-03 | 4.24E-03 | 3.2 |
| LRRC17 | Leucine rich repeat containing 17 | 1.74E-03 | 2.40E-03 | 2.8 |
| MARCKS | Myristoylated alanine-rich kinase C substrate | 3.93E-03 | 4.50E-03 | 2.8 |
| NOTCH3 | Notch homolog 3 (Drosophila) | 1.65E-03 | 2.36E-03 | 3.6 |
| PDIR | protein disulfide isomerase-related | 4.86E-04 | 1.08E-03 | 2.1 |
| POSTN | Periostin, osteoblast specific factor | 1.10E-04 | 3.15E-04 | 3.5 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | 1.01E-03 | 1.68E-03 | 2.1 |
| S100A10 | S100 calcium binding protein A10 | 1.95E-03 | 2.52E-03 | 2.8 |
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 9.51E-05 | 3.15E-04 | 1.7 |
| SLC2A13 | Solute carrier family 2 13 | 5.41E-03 | 5.85E-03 | 2.8 |
| TAOK1 | TAO kinase 1 | 1.51E-04 | 4.03E-04 | 1.7 |
| TJP1 | Tight junction protein 1 (zona occludens 1) | 6.87E-04 | 1.31E-03 | 1.6 |
| TNC | Tenascin C (hexabrachion) | 9.20E-05 | 3.15E-04 | 5.3 |
| UBE2E3 | Ubiquitin-conjugating enzyme E2E 3 | 8.72E-04 | 1.52E-03 | 3.7 |
| WDR1 | WD repeat domain 1 | 4.01E-06 | 8.01E-05 | 1.6 |
| WISP1 | WNT1 inducible signaling pathway protein 1 | 3.93E-03 | 4.50E-03 | 3.4 |