Figure 2. Surrogate markers of bone metabolism in serum of normal, tumor-bearing and zoledronic acid treated mice.

(A) Levels of the osteoblast marker, osteocalcin were reduced in serum of zoledronic acid treated mice. (B) Tartrate-resistant acid phosphatase 5b, an indicator of osteoclast activity, was also reduced with treatment. Points on the graph represent serum levels for individual mice while bars show the position of the means within each group. Statistical analysis was performed using one-way ANOVA for analysis followed by Tukey's post test. *** p<0.001.