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. 2011 May 16;6(5):e19651. doi: 10.1371/journal.pone.0019651

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Barbier et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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This network is the most significative network among five significative networks obtained using the 58 PL-regulated genes with IPA (supplementary data). Twenty genes of this network are differentially expressed in HBEC in presence of PL (colored in green for the down-regulated gene and red for up-regulated genes). The molecules hedged in orange belong to the main canonical pathways linked to this network (Acute phase response-, B cell receptor-, Chemokine-, Erythropoietin-, Glucocorticoid receptor-, IL6-, IL8-, IL10-, IL12-, PPAR-, RAR-, TREM-1-signaling, IRF, LXR/RXR, PPARa/RXRa, RAR activation, Role of pattern recognition receptor, Role of PKR in IFN induction, Hepatic cholestasis, Hepatic fibrosis).