Table 2. Multi-way analysis of variance for HBEC gene expression data.

Factor	Sum of square	DFa	Mean square	F	P-value
gene	849219.05	4501	188.67	274.11	<0.00001
RBC	0.37	2	0.18	0.27	-
TNF	0.17	1	0.17	0.24	-
PL	4.37	1	4.37	6.56	0.01013
time	0.1	1	0.1	0.15	-
gene×RBC	6341.37	9002	0.7	1.02	0.0416
gene×TNF	6497.82	4501	1.44	2.1	<0.00001
gene×PL	4644.08	4501	1.03	1.5	<0.00001
gene×time	5355.23	4501	1.19	1.73	<0.00001
gene×time×TNF	3250.75	4501	0.72	1.09	0.00005
gene×time×PL	3264.17	4501	0.73	1.09	0.00002
gene×TNF×PL	3219.91	4501	0.72	1.07	0.00029
gene×time×RBC×TNF	6177.54	9002	0.69	1.03	0.0214
gene×time×RBC×PL	6256.12	9002	0.69	1.04	0.0026
Residualb	176809.89	265625	0.67	-	-
Total	1070570.59	324143	3.3	-	-

^aDegree of freedom.

^bThe residual corresponds to the variance that was not explained by the model.