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. 2011 May 16;6(5):e19689. doi: 10.1371/journal.pone.0019689

Figure 1. Trehalose induces secondary structural elements in the ID AF1.

Figure 1

(A) Diagram of human GR protein showing major functional domains. Far-UV CD spectra of GR AF1 protein in the absence and presence of increasing concentrations of trehalose (B) or TFE (C). (D) Trehalose-induced conformational transition of AF1. The nonlinear least squares best fit of experimental data to two-state model of protein folding/denaturation using linear extrapolation methods gives apparent thermodynamic parameters of trehalose-induced folding: ΔG and m (expressed as kcal/mol; shown in the box). (E) A linear plot showing TFE-induced helical structure in AF1.