Table 1. Summary of the behavioral results.

Type of HD-like symptoms	Behavioral domain	Behavioral Test	Effects of the R6/1 mutation	Presence in R6/1 MALES	Presence in R6/1 FEMALES
social	social interest	three compartment	lack of social interest	+	+
social	social interaction	interaction with a same sex juvenile	reduced affiliation	+	−
social	social interaction	interaction with an adult female	reduced affiliation	+	−
social	communication	interaction with an adult female	deficits in ultrasonic vocalizations	+	+/−
non-social	circadian activity	38 hrs-activity monitoring	mildly altered activity patterns	+/−	+/−
non-social	acoustic startle and its plasticity	startle test	normal startle, habituation and PPI	−	−

Social and non social symptoms were detected in R6/1 mice, Social HD-like deficits were mostly observed in R6/1 males. + = present, − = absent, +/− = partially present, i.e., detected only on duration (for ultrasonic vocalizations) or on some time-bins (for circadian activity).