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. Author manuscript; available in PMC: 2012 Jun 11.
Published in final edited form as: Eur J Pharmacol. 2011 Jan 1;660(1):103–110. doi: 10.1016/j.ejphar.2010.11.040

Figure 5.

Figure 5

Dopachrome tautomeraseinduction in melanocyte co -cultures. Melanocytes were either melanocortin MC1 receptor wild type (WT–QF1106 strain), heterozygous for R151C (QF1200 strain) or heterozygous for R160W (QF1100 strain). Co-cultures of melanocytes with keratinocytes were treated with the following compounds: C = Control, N = 20nM NDP-MSH or F = 10uM forskolin, for four days, then total cell extracts were used for western immuno-blotting with dopachrome tautomerase(Santa Cruz) and GAPDH antibodies. This blot is representative of responses seen in three different wild type and variant strains.