Table 1.
MC1R variant alleles in hair and skin colour.
| MC1R Allele | Red hair % | Blonde hair % | Light brown hair % | Dark brown hair % | Black hair % | Fair skin % | |
|---|---|---|---|---|---|---|---|
| Wild Type | +/+ | 0 | 10.4 | 34.7 | 48.6 | 6.3 | 21 |
| +/V60L | +/r | 0.4 | 14.6 | 34.8 | 44.7 | 5.5 | 24 |
| V60L/V60L | r/r | 2.5 | 17.5 | 32.5 | 47.5 | 0 | 50 |
| +/D84E | +/ R | 0 | 21.7 | 34.8 | 43.5 | 0 | 64 |
| D84E/D84E | R/R | - | - | - | - | - | - |
| +/V92M | +/r | 1.4 | 15.9 | 35.9 | 42.3 | 4.6 | 39 |
| V92M/V92M | r/r | 0 | 0 | 20 | 70 | 10 | 43 |
| +/R142H | +/R | 0 | 15.4 | 15.4 | 61.5 | 7.7 | 10 |
| R142H/R142H | R/R | - | - | - | - | - | - |
| +/R151C | +/R | 0.9 | 23.5 | 42.6 | 30.9 | 2.2 | 45 |
| R151C/R151C | R/R | 74.1 | 14.8 | 3.7 | 7.4 | 0 | 94 |
| +/I155T | +/r | 0 | 24 | 36 | 40 | 0 | 31 |
| I155T/I155T* | r/r | 0 | 0 | 0 | 100 | 0 | 0 |
| +/R160W | +/R | 4 | 14.6 | 45.5 | 34.8 | 1.1 | 44 |
| R160W/R160W | R/R | 57.1 | 14.3 | 14.3 | 14.3 | 0 | 50 |
| +/R163Q | +/r | 0 | 16 | 40 | 42 | 2 | 24 |
| R163Q/R163Q | r/r | 0 | 0 | 50 | 25 | 25 | 50 |
| +/D294H | +/R | 0 | 14 | 34 | 48 | 4 | 40 |
| D294H/D294H* | R/R | 100 | 0 | 0 | 0 | 0 | 100 |
Adapted from data in (Beaumont et al., 2007).
*
For these genotypes data was obtained from only one individual. R = high penetrance allele, r = low penetrance allele, r= familial association with R/functionally classified asequivalent to r.