. Author manuscript; available in PMC: 2012 Jun 11.

Published in final edited form as: Eur J Pharmacol. 2011 Jan 3;660(1):125–130. doi: 10.1016/j.ejphar.2010.12.020

Table 1.

Receptor mutation on NDP-α-MSH binding affinity and potency

	Receptor binding affinity and potency
Residue mutation	hMC1R		hMC2R		hMC3R		hMC4R		hMC5R
TM2 (2.6)	E94	↓	E80	↓	E131	↓	E100	↓	E92	↓
TM3 (3.25)	D117	↓	D103	↓	D154	↓	D122	↓	D115	↓
TM3 (3.29)	D121	↓	D107	↓	D158	↓	D126	↓	D119	↓
TM6 (6.48)	W254	↓	W232	↓	W292	↓	W258	↓	W251	↓
TM6 (6.51)	F257	↓	F235	↓	F295	↓	F261	↓	F254	↓
TM6 (6.54)	H260	↓	H238	↓	H298	↓	H264	↓	H257	↓

^↓

binding affinity and potency decrease.