Table 1.
* Bivariate correlations in DAT +/+ and DAT+/- mice
| Behavioral Variables | Neurochemical Variables | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| AVG g/kg | AVG Entries | AVG Loco | 5 pulses | 10 pulses | 20 pulses | 40 pulses | DAT Half-life Baseline | ||
| AVG Entries (pellet retrieval) | r p= N |
0.181 0.203 51 |
|||||||
| AVG Locomotion | r p= N |
-0.128 0.370 51 |
-0.490 0.000 51 |
||||||
| 5 pulses | r p= N |
-0.128 0.37 51 |
-0.016 0.91 51 |
-0.047 0.74 51 |
|||||
| 10 pulses | r p= N |
0.270 0.055 51 |
0.039 0.784 51 |
-0.017 0.908 51 |
0.847 0.000 51 |
||||
| 20 pulses | r p= N |
0.274 0.050 51 |
0.069 0.630 51 |
-0.033 0.816 51 |
0.758 0.000 51 |
0.892 0.000 51 |
|||
| 40 pulses | r p= N |
0.327 0.019 51 |
0.150 0.293 51 |
-0.114 0.428 51 |
0.689 0.000 51 |
0.845 0.000 51 |
0.862 0.000 51 |
||
| DA Half-Life Baseline | r p= N |
-0.256 0.086 46 |
0.109 0.471 46 |
-0.040 0.791 46 |
-0.347 0.018 46 |
-0.393 0.007 46 |
-0.417 0.004 46 |
-0.387 0.008 46 |
|
| DA Half-Life nomifensine | r p= N |
-0.344 0.026 42 |
-0.325 0.036 42 |
0.225 0.151 42 |
-0.120 0.447 42 |
-0.076 0.632 42 |
-0.176 0.266 42 |
-0.270 0.084 42 |
0.354 0.021 42 |
Relationships between behavioral variables and indices of dopaminergic function.
r= Pearson product moment correlations, P= Significance levels, N=number of mice in each correlation. Bold P values indicate significant correlations. Note that 5 mice were eliminated prior to determining DA half-life at baseline due to electrode failure and 4 animals were eliminated from the pre/post nomifensine analysis of DA half-life due to failure to respond to the nomifensine injection.