Table 1.
Amino acid sequences and mass spectral analysis for compstatin peptides used in SPR experiments.
| Peptide # |
Peptide Name | Amino Acid Sequencea | Mass Spectral Analysisb |
|---|---|---|---|
| I | Linear | I AVVQDWGHHRA T-(PEG)8-K-(biotin)-NH2 | 2267.06 |
| II | Parent | I[CVVQDWGHHRC]T-(PEG)8-K-(biotin)-NH2 | 2327.6 |
| III | W4/A9 | I[CVWQDWGAHRC]T-(PEG)8-K-(biotin)-NH2 | 2349.2 |
| IV | SQ027 | W[CVWQDWGTNRC]W-(PEG)8-K-(biotin)-NH2 | 2514.9 |
| V | SQ059 | D[CVWQDWGTNKC]W-(PEG)8-K-(biotin)-NH2 | 2414.93 |
| VI | SQ086 | Q[CVWQDWGQNQC]W-(PEG)8-K-(biotin)-NH2 | 2454.4 |
| VII | W4/A9/W13 | Ac-I[CVWQDWGAHRC]W-(PEG)8-K-(biotin)-NH2 | 2476.0 |
| VIII | W1/W4/A9 | Ac-W[CVWQDWGAHRC]T-(PEG)8-K-(biotin)-NH2 | 2464.0 |
| IX | W1/W4/A9/W13 | Ac-W[CVWQDWGAHRC]W-(PEG)8-K-(biotin)-NH2 | 2548.7 |
| X | W(i, i+3)/A9 | Ac-W[CVWQDWGAWRC]W-(PEG)8-K-(biotin)-NH2 | 2598.5 |
a
Brackets denote cyclization. Sequence differences of various compstatin peptides from parent compstatin are shown in bold characters.
b
Molecular masses were provided by Abgent Inc.