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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Chem Biol Drug Des. 2011 Apr 26;77(6):431–440. doi: 10.1111/j.1747-0285.2011.01111.x

Table 3.

Compstatin peptide IC50 values from human C3b ELISA experiments.

Peptide
#		 Peptide Name Amino Acid Sequencea Mass
Spectral
Analysisb 		Concentration
Range (µM)		 IC50
(µM)
II Parent Ac-I[CVVQDWGHHRC]T-NH2 1591.47 64-0.125 0.47
III W4/A9 Ac-I[CVWQDWGAHRC]T-NH2 1613.20 8-0.016 0.11
IV SQ027 W[CVWQDWGTNRC]W-NH2 1735.73 32-0.063 0.94
V SQ059 Ac-D[CVWQDWGTNKC]W-NH2 1678.27 64-0.500 4.73
VI SQ086 Q[CVWQDWGQNQC]W-NH2 1675.87 64-0.125 1.98
VII W4/A9/W13 Ac-I[CVWQDWGAHRC]W-NH2 1697.87 64-0.125 1.08
VIII W1/W4/A9 Ac-W[CVWQDWGAHRC]T-NH2 1685.60 16-0.031 0.29
IX W1/W4/A9/W13 Ac-W[CVWQDWGAHRC]W-NH2 1771.20 64-0.125 1.09
a

Brackets denote cyclization. Sequence differences of various compstatin peptides from parent compstatin are shown in bold characters.

b

Molecular masses were provided by Abgent Inc.