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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Cell Signal. 2011 Mar 16;23(8):1291–1298. doi: 10.1016/j.cellsig.2011.03.010

Figure 7. Model summarizing the new findings of this study.

Figure 7

PLD enzymatic action, after been increased due to the binding to Grb2-SH2 via Y169, cooperates with Rac2, and the three molecules stimulate actin polymerization and consequently, membrane ruffle formation. Since membrane ruffling precedes cell migration, the results herein provide a novel mechanism for control of membrane dynamics, crucial for the physiology of leukocytes.