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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Osteoarthritis Cartilage. 2011 Mar 23;19(5):550–556. doi: 10.1016/j.joca.2011.01.023

Table 3.

Results of random-effects pooling for studies that reported estimates of responsiveness by different study characteristics

Number of Estimates I-squared (95% CI) SRM (95% CI)

Overall 43 0.82 (0.76, 0.86) 0.33 (0.26, 0.41)

Knee Flexion
 Extended 16 0.19 (0.00, 0.55) 0.32 (0.26, 0.37)
 Flexed 27 0.88 (0.84, 0.91) 0.34 (0.22, 0.45)

Fluoroscopy
 Fluoro 23 0.83 (0.76,0.88) 0.38 (0.27, 0.48)
 No Fluoro 20 0.79 (0.69 0.86) 0.28 (0.17, 0.39)

Measurement Method
 Manual 18 0.80 (0.70, 0.87) 0.38 (0.26, 0.50)
 Computerized 24 0.84 (0.77, 0.89) 0.31 (0.20, 0.41)

Study Type
 RCT 19 0.82 (0.73, 0.88) 0.30 (0.20, 0.40)
 Cohort 24 0.82 (0.74, 0.87) 0.36 (0.24, 0.49)

Follow-up Time
 1-year or less 21 0.56 (0.27, 0.73) 0.24 (0.15, 0.32)
 1–2 years 10 0.80 (0.63, 0.89) 0.25 (0.13, 0.37)
 Greater than 2 years 12 0.88 (0.81, 0.93) 0.57 (0.39, 0.75)

Reader blinded to order of radiographs
 Yes 19 0.76 (0.63, 0.85) 0.30 (0.19, 0.40)
 No 2 0.59 (0.00, 0.90) 0.55 (0.33, 0.76)
 Unknown 22 0.85 (0.78, 0.89) 0.35 (0.23, 0.46)

Knee Flexion by Follow-up Time
 Extended/1-year or less 9 0.00 (0.00, 0.63) 0.26 (0.19, 0.34)
 Extended/1–2 years 2 0.61 (0.00, 0.91) 0.38 (0.10, 0.65)
 Extended/Greater than 2 years 5 0.32 (0.00, 0.74) 0.34 (0.24, 0.44)
 Flexed/1-year or less 12 0.68 (0.42, 0.83) 0.19 (0.06, 0.32)
 Flexed/1–2 years 8 0.82 (0.65, 0.90) 0.22 (0.08, 0.36)
 Flexed/Greater than 2 years 7 0.88 (0.78, 0.94) 0.71 (0.44, 0.98)

Fluoroscopy by Follow-up Time
 Fluoro/1-year or less 9 0.33 (0.00, 0.69) 0.29 (0.18, 0.39)
 Fluoro/1–2 years 7 0.81 (0.62, 0.91) 0.29 (0.14, 0.44)
 Fluoro/Greater than 2 years 7 0.87 (0.75, 0.93) 0.58 (0.36, 0.80)
 No Fluoro/1-year or less 12 0.61 (0.28, 0.79) 0.21 (0.10, 0.32)
 No Fluoro/1–2 years 3 0.82 (0.45, 0.94) 0.15 (−0.13, 0.42)
 No Fluoro/Greater than 2 years 5 0.89 (0.78, 0.95) 0.56 (0.24, 0.87)

Measurement Method by Follow-up Time
 Manual/1-year or less 8 0.20 (0.00, 0.63) 0.28 (0.17, 0.38)
 Manual/1–2 years 2 0.92 (0.73, 0.98) 0.19 (−0.44, 0.82)
 Manual/Greater than 2 years 8 0.87 (0.77, 0.93) 0.51 (0.31, 0.71)
 Computerized/1-year or less 12 0.68 (0.42, 0.83) 0.21 (0.08, 0.33)
 Computerized/1–2 years 8 0.78 (0.56, 0.89) 0.26 (0.13, 0.38)
 Computerized/Greater than 2 years 4 0.90 (0.77, 0.96) 0.68 (0.31, 1.06)

Study Type by Follow-up Time
 RCT/1-year or less 10 0.60 (0.19, 0.80) 0.21 (0.11, 0.32)
 RCT/1–2 years 5 0.87 (0.72, 0.94) 0.24 (0.07, 0.41)
 RCT/Greater than 2 years 4 0.51 (0.00, 0.84) 0.56 (0.41, 0.70)
 Cohort/1-year or less 11 0.51 (0.03, 0.75) 0.26 (0.13, 0.40)
 Cohort/1–2 years 5 0.69 (0.20, 0.88) 0.26, (0.06, 0.46)
 Cohort/Greater than 2 years 8 0.92 (0.86, 0.95) 0.57 (0.30, 0.85)