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. Author manuscript; available in PMC: 2012 Jun 11.
Published in final edited form as: Eur J Pharmacol. 2011 Jan 1;660(1):80–87. doi: 10.1016/j.ejphar.2010.10.101

Figure 6.

Figure 6

Locomoter assay to assess visceral illness-like effects and gross behavioral changes of JRH322-18 relative to saline treatment in wild type mice. Mean ± S.E.M. distance traveled (in meters) during 48h in running wheel cages for mice injected into the 3rd ventricle with 1µl of either saline (filled circles, n=5) or JRH322-18 (open box, n=4). X-axis is time spent in running wheel cages in hours, Y-axis is distance traveled in meters. Dashed vertical lines show transition points during light-dark cycle, horizontal bars at top denote light phase (open bar) or dark phase (filled bar). No statistically significant differences resulted and the JRH322-18 treated group demonstrated a slightly increased running wheel activity at the 36 to 48 h post injection time points.