. Author manuscript; available in PMC: 2012 Jun 11.

Published in final edited form as: Eur J Pharmacol. 2011 Jan 1;660(1):80–87. doi: 10.1016/j.ejphar.2010.10.101

Table 1.

Summary of in vitro mouse melanocortin receptor pharmacology.

Name	Structure	Functional Activity (nM) mMC3R	Binding Affinity (nM) mMC3R	Functional Activity (nM) mMC4R	Binding Affinity (nM) mMC4R
α-MSH	Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂	Agonist 0.80±0.14	ND	Agonist 5.40±0.62	ND
NDP-MSH	Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH₂	Agonist 0.098±0.013	0.52±0.10	Agonist 0.21±0.03	0.91±0.85
MTII	Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH₂	Agonist 0.16±0.03	1.85±0.35	Agonist 0.087±0.008	0.50±0.13
SHU9119	Ac-Nle-c[Asp-His-DNal(2’)-Arg-Trp-Lys]-NH₂	Antagonist^* 0.32	3.2±1.1	Antagonist 0.040	0.38±0.10
JRH887-9	Ac-His-DPhe-Arg-Trp-NH₂	Agonist 160±9.2	ND	Agonist 17±2.8	ND
JRH322-18	Ac-His-(pI)DPhe-Arg-Trp-NH₂	Antagonist^* 50±1.1	270±146	Agonist 25±9.8	4.81±4.5
AGRP(87-132)		Antagonist 1.4	2.8±0.4	Antagonist 0.41	3.0±0.3

ND indicates values not reported.

Indicates that the antagonists also possess partial agonist activity at the mMC3R. The indicated error represents the standard error of the mean.