Table 2. Summary of Test/Retest and Test/Block Experiments using VT, BPP, and BPND.
The third column is the average, standard deviation, and range of values over the test/retest and baseline scans (n = 9). The fourth column is the average, standard deviation, and range of the percent difference as found in the test/retest study (n = 6). The fifth column is the average, standard deviation, and range of the percent block as found in the test/block study (n = 6). VT averages and ranges were calculated over all regions, except for the reference region (cerebellar grey matter, CGM), which is listed separately. VT and BPP values were calculated over all high binding regions using an arterial input function and an unconstrained two-tissue compartment modeling method. BPND values were calculated using the Logan graphical approach, without blood input information.
| Outcome Measure | Percent Difference (%) | Percent Block (%) | ||
|---|---|---|---|---|
| VT (mL/cc) | Average | 5.14±0.99 | 5.9±4.3 | −40.5±18.5 |
| Range | 4.01 : 6.06 | 4.3 : 8.2 | −34.0 : −51.7 | |
| CGM | 2.90±0.62 | 6.0±0.7 | −7.1±30.0 | |
| BPP (mL/cc) | Average | 2.24±0.70 | 11.7±6.1 | −83.5±15.0 |
| Range | 1.11 : 3.16 | 4.4 : 17.7 | −76.3 : −90.8 | |
| BPND (unitless) | Average | 0.79±0.26 | 11.5±7.0 | −80.3±15.5 |
| Range | 0.39 : 1.12 | 6.3 : 15.8 | −72.4 : −88.2 |