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Endstage PBC usually results in a well-developed cirrhosis (A, H&E, raagnifica tion ×40), which is probably a result of activity at the edge of the limiting plate as seen in B (H&E, magnification ×250). A loss of small bile ducts and an obliterative arteropathy with prominent subintimal foam cells is seen in chronic rejection (C, H&E, magnification ×40). A well-developed cirrhosis is uncommon in end-stage liver-rejection (D, H&E, magnification ×40).
