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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Trends Microbiol. 2011 Feb 15;19(4):174–183. doi: 10.1016/j.tim.2011.01.003

Figure 1.

Figure 1

Schematic illustration of HAdv5 genome. The HAdv5 genome consists of a 35 kb linear double stranded DNA that is covalently linked to viral terminal proteins (TP) at the 3′ ends. The viral genome contains five early transcription units (E1A, E1B, E3, E4 and E2) and one major late transcription unit. The major late transcript is differentially processed into five groups of late mRNAs (L1–L5) to which three leader sequences are attached by RNA splicing. The late mRNAs code for various viral structural proteins. The left most 14% of the genome contains the E1A and E1B genes that constitute the transforming genes. l-E1A indicates the large E1A protein and s-E1A indicates the small E1A protein. The early region E4 of different HAdv species encodes multiple proteins and at least three of them, Orf 1, Orf 3 and Orf 6 (indicated by 1, 3 and 6) exhibit transforming activities.