TABLE 2.
ALVEOLAR TYPE II CELLS EXPRESS ERYTHROID-SPECIFIC GENES
| MLE-15 | ATII Primary Cells | MH-S Macrophage | BB88 Erythroid Noninduced | BB88 Erythroid Induced | |
|---|---|---|---|---|---|
| HBA | + | ++ | Negative | + | +++ |
| HBB | + | ++ | Negative | + | +++ |
| GATA1 | + | + | Negative | ++ | +++ |
| GATA2 | ++ | + | Negative | +++ | ++ |
| NFE2 | + | + | Negative | + | + |
| ALAS2 | ± | ++ | Negative | ++ | +++ |
| SP-B | +++ | +++ | Negative | Negative | Negative |
| SP-C | +++ | +++ | Negative | Negative | Negative |
| TTF-1/Nkx2-1 | ++ | ++ | Negative | Negative | Negative |
| SLC4A1/band3 | Negative | Negative | Negative | + | +++ |
Definition of abbreviations: HBA, hemoglobin α; HBB, hemoglobin β major; NFE2, nuclear factor (erythroid-derived 2); ALAS2, δ-aminolevulinate synthase 2; SP-B, surfactant protein B; SP-C, surfactant protein; TTF-1, thyroid transcription factor cells, also known as Nkx2-1); SLC4A1, solute carrier family 4 (anion exchanger), member 1, also known as band 3. “±” indicates extremely low concentrations. MH-S and BB88 are ATCC cell designations as described in Methods.