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. 2010 Jan 29;44(3):285–292. doi: 10.1165/rcmb.2009-0400OC

Figure 5.

Figure 5.

Adoptive transfer of DCs from allergen-naive neonates. Splenic CD11c+ DCs were transferred from 14-day-old allergen-naive neonates born to asthmatic mothers (see protocol in Figure 1) into recipient 3-day-old normal mice (group Rcp:AsBa14). Control recipients were injected with splenic DCs from neonates born to normal females (Rcp:NoBa14) or with PBS alone (PBS Ctrl). All recipients were subjected to an intentionally “suboptimal” protocol, with only one injection of OVA on Day 4 of life. Positive controls received a second OVA injection on Day 9 (POS Ctrl). After aerosol challenges with OVA, pups were analyzed for AHR and AI. Findings indicate (a) increased airway responsiveness in Rcp:AsBa14 compared with Rcp:NoBa14, (b) increased BAL eosinophilia in Rcp:AsBa14 compared with Rcp:NoBa14, and (c) an increased pulmonary inflammation score in Rcp:AsBa14, which was minimal in Rcp:NoBa14. *P < 0.05.