Table 2.
Genes found in altered modules of head and neck squamous cell carcinoma (HNSCC).
| Module | Status | Gene symbol | p-value |
|---|---|---|---|
| Negative lymph node (20 samples) | |||
| Protein biding | repressed | FOSB | 4.1E-31 |
| KLK6 | 5.7E-18 | ||
| AREG | 1.3E-11 | ||
| CCL20 | 4.0E-08 | ||
| IL1B | 7.5E-05 | ||
| MYC | 2.0E-04 | ||
| INHBA | 7.0E-03 | ||
| EGFR | 1.4E-02 | ||
| AKT1 | 2.1E-02 | ||
| Regulation of apoptosis | repressed | SPHK1 | 9.0E-09 |
| INHBA | 9.0E-09 | ||
| AKT1 | 9.7E-03 | ||
| KLK pathway | induced | KLK13 | 4.0E-15 |
| KLK7 | 2.8E-05 | ||
| KLK6 | 1.5E-02 | ||
| SERPINA3 | 1.7E-02 | ||
| Positive lymph node (61 samples) | |||
| KLK pathway | repressed | KLK13 | 4.0E-15 |
| KLK7 | 2.8E-05 | ||
| KLK6 | 1.5E-02 | ||
| SERPINA3 | 1.7E-02 | ||
| Recurrent tumors (20 samples) | |||
| Cell-cell signaling | induced | IL1F9 | 4.1E-20 |
| AREG | 5.5E-15 | ||
| INHBA | 1.5E-12 | ||
| BST2 | 7.6E-10 | ||
| CCL20 | 2.1E-3 | ||
| KLK6 | 8.9E-3 | ||
| Non-recurrent tumor (27samples) | |||
| Cell-cell signaling | repressed | IL1F9 | 4.1E-20 |
| AREG | 5.5E-15 | ||
| INHBA | 1.5E-12 | ||
| BST2 | 7.6E-10 | ||
| CCL20 | 2.1E-3 | ||
| KLK6 | 8.9E-3 | ||
| Extracellular region | repressed | INHBA | 6.6E-15 |
| POSTN | 3.0E-9 | ||
| KLK13 | 1.9E-6 | ||
| AREG | 2.4E-6 | ||
| MMP13 | 7.3E-4 | ||
| KLK6 | 1.6E-2 | ||
HNSCC patients were classified according to pathologic lymph node status (positive or negative) or tumor recurrence (recurrent or non-recurrent tumor) after treatment (surgery with neck dissection followed by radiotherapy) and samples from primary tumors were collected. Gene expression was assessed by microarray and functional module analysis was performed. Functional modules were defined according to the following databases: Biocarta], GeneDecks, Gene Ontology, and to the Kyoto Encyclopedia of Genes and Genomes Pathway Database (KEGGPD).